Virb

There are a few web pages that I always have open. Google Reader, Vitalist, and Workamajig (yikes). Sites like Mint and, (shameless plug) Twuffer are even beginning to make the tabs-never-to-be-closed list.
Fluid is written by ex-Apple Dashboard developer Todd Ditchendorf. It allows you to create Site Specific Browsers, or SSBs. Thanks to Fluid, "you can [...] type="text/javascript">SHARETHIS.addEntry({ title: "Turn web pages into stand-alone apps with Fluid", url: "http://www.daynw.com/turn-web-pages-into-stand-alone-apps-with-fluid/" });>